The research framework report examines existing research on the social determinants of health from an Indigenous perspective. In addition to examining the role of poverty, graduation rates and access to healthy food, to name a few, the framework also focuses on the role of historical trauma, self determination and access to cultural practices to better understand the causes of Native American childhood obesity. This research framework is designed to help the NB3 Foundation build a fuller understanding of the root causes and solutions to childhood obesity in Indian Country.